OUR PEOPLE
Jeffrey Agar
The Agar group characterizes post-translational modifications of proteins and changes in protein, peptide, and lipid expression that occur during ALS, and then determines which of these changes have structural or toxic consequences. Because ALS begins with the death of a single type of cell, the motor neuron, we have developed numerous methods for the analysis of single cells by mass spectrometry. The Agar group specializes in mass spectrometry, including ultra-high mass resolution “top-down” mass spectrometry and mass spectrometry imaging methods, and has developed both analytical methods (“Matrix solution fixation” introduced by Agar YR 2007, automated funnel-skimmer dissociation, Karabacak 2008 and Cobb 2010, single-cell mass spectrometry imaging of mammalian cells, Agar YR 2010 and Boggio 2011) and computational tools (Karabacak 2008 introduced “Big Mascot” or Mascot TD database search engine, Li 2008 and 2010 introduce isotope calculator, a suite for mass spectrometry imaging applications is functional and to-be-submitted).
Jared Auclair
Jared R. Auclair is currently the Director of Executive Training and Biotechnology Programs in the department of chemistry and chemical biology at Northeastern University. In addition to being Director of Biotechnology, Dr. Auclair also directs the Biopharmaceutical Analysis Training Laboratory, the Asia-Pacific Economic Cooperation Center of Regulatory Excellence in Biotherapeutics and oversees the International Council for Harmonisation training. These appointments allow Dr. Auclair to collaborate with both academic researchers and industry in the area of biopharmaceutical development and analysis, as well as international regulators on best practices and new advances in the regulatory sciences for drug approvals.
Christa Dhimo
Christa is a Professor of the Practice, Biotechnology Programs at Northeastern’s Professional Science Master’s in Biotechnology at the College of Science. In this role, she bridges her real-world expertise with an academic application while serving as Faculty Lead for the Enterprise Concentration and contributing to the competitive global growth of the program. She applies that same bridging of real-world and academia to additional service at Northeastern with her work as a D’Amore-McKim School of Business (DMSB) Domestic Consulting Sponsor and Mentor; a Faculty Affiliate and Program Designer for Corporate Learning’s Leadership, Strategy and Execution Courses; an Adjunct Professor for Strategic Portfolio Management at the College of Professional Studies; and a Distinguished Speaker for the Gordon Engineering Leadership Program.
Tania Konry
Tania Konry’s lab is focused on developing novel Bio-MEMS approaches to advance point of care diagnostics, cell culture and drug screening and delivery methods. We have developed Lab-on-a-Chip (LOC) devices that integrate several laboratory functions such as real time monitoring of target clinically relevant analyte, proteomics, genomics, cell-cell interactions as well as cell secretion and surface monitoring of single cells on a micro-chip. The advantages of the microfluidic based LOC developed by our lab include, the pico and nano-liter volumes, elimination of cross-contamination, the fast and efficient mixing of the reagents and gases and the ability to manipulate and analyze cells at a very high-throughput.
Wei Xie
Wei Xie is an assistant professor in the Department of Mechanical and Industrial Engineering and an affiliated faculty in the Biopharmaceutical Analysis Training Lab (BATL) at Northeastern University. Her research interests focus on interpretable Artificial Intelligence (AI), computer simulation, data analytics, design of experiments, data-driven stochastic optimization, process analytical technology (PAT), systems biology, synthetic biology, cyber-physical system (CPS) learning and risk management with applications, including biopharmaceutical manufacturing supply chains, healthcare systems, and smart power grids with renewable energy. She currently serves as Associate Editor for “ACM Transactions on Modeling and Computer Simulation” and Northeastern representative Technical Activity Committee (TAC) for “National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL).”
CONNECT WITH US
We welcome questions from potential students, seasoned scientists, and industry partners. Please contact us at bioinnovation@northeastern.edu